Clinical comparison of a NGS-based approach vs. conventional testing methods*
PathoQuest has completed a proof of concept clinical study which compared the ability of a NGS-based testing approach identify pathogens in patients with suspected infections versus the use of conventional testing methodologies was conducted at two prominent medical centers in France. This study:
- A total of 101 patients were enrolled in the study.
- All patients enrolled were immunocompromised and 23% of the patients were neutropenic.
- The study cohort included the following reasons of immunosuppression:
– Anti-cancer chemotherapy
– Immunosuppressive treatment following solid organ transplantation
– Stem cell transplant recipients
– Primitive immunodeficiency
– Other causes of immunosuppression
- The study compared PathoQuest’s next generation sequencing (NGS) based testing approach to standard testing methodologies (blood cultures and targeted PCR testing).
- Testing results from both arms of the study were medically adjudicated by a panel of clinical experts in order to confirm that the pathogens identified were likely to be associated with the patient’s infection-related symptoms and clinical presentation.
The results of this study have been recently published in the peer-reviewed journal Clinical Microbiology and Infection, an official publication of ESCMID. Link to publication abstract.
*Parize P, Muth E, Richaud C, et al. Untargeted next-generation sequencing-based first-line diagnosis of infection in immunocompromised adults: a multicentre, blinded, prospective study.Clin Microbiol Infect. 2017 Feb 10. doi: 10.1016/j.cmi.2017.02.006.